https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54890 Wed 20 Mar 2024 13:17:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27319 Wed 11 Apr 2018 15:35:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50150 50% at baseline). Untargeted gas chromatography–mass spectrometry analysis was performed to analyse baseline levels of 68 serum metabolites. Of the nine metabolites that differentiated placebo and NAC groups, five were amino acids with lower levels in the NAC responder group compared with the NAC non-responders. Further analysis generated a predictive model of MADRS improvement including glycine, norleucine, threonine, proline, phenylalanine, tyrosine, glutamic acid, lysine and leucine (R2 = 0.853; adjusted R2 = 0.733). This prediction model predicted 85% of the variance in MADRS outcome after adjunctive treatment with NAC. BD participants with lower serum levels of free amino acids at baseline may be more likely to respond to adjunctive treatment with NAC.]]> Wed 05 Jul 2023 14:11:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:483 Thu 25 Jul 2013 09:09:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7124 Sat 24 Mar 2018 08:34:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20953 Sat 24 Mar 2018 08:06:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21387 Catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism, a common genetic variant known to affect cognition and prefrontal dopamine levels. Participants were 429 schizophrenia/schizoaffective cases from the Australian Schizophrenia Research Bank (ASRB). Cognitive performance was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Controlled Oral Word Association Test (COWAT), Letter Number Sequencing (LNS) test, and the Wechsler Test of Adult Reading (WTAR). Hierarchical regression was used to test the main effects and additive interaction effects of genotype and childhood trauma in the domains of physical abuse, emotional abuse, and emotional neglect, on cognition and symptom profiles of clinical cases. Consistent with previous findings, COMT Val homozygotes performed worse on cognitive measures in the absence of childhood adversity. In addition, a significant interaction between COMT genotype and physical abuse was associated with better executive function in Val homozygotes, relative to those of the same genotype with no history of abuse. Finally, the severity of positive symptoms was greater in Met carriers who had experienced physical abuse, and the severity of negative symptoms in Met carriers was greater in the presence of emotional neglect. These results suggest that the possible epigenetic modulation of the expression of the COMT Val¹⁵⁸Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers.]]> Sat 24 Mar 2018 08:05:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20133 Sat 24 Mar 2018 07:51:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5524 Sat 24 Mar 2018 07:46:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26307 Sat 24 Mar 2018 07:40:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29669 Sat 24 Mar 2018 07:32:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28189 Sat 24 Mar 2018 07:23:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4889 Sat 24 Mar 2018 07:21:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22607 2 = 3.48, p = 0.062 and X² = 0.036, p = 0.036, respectively). Cognitive test scores were significantly lower in patients than in controls on all scales (all p < 0.001) except for the visuospatial/constructional index (p > 0.05). There were significant genotype effects on delayed memory score (p = 0.013), the RBANS total score (p = 0.028) and language score (p = 0.034). Further analysis showed that the language score significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.007) in patients but not in controls (p > 0.05), and the delayed memory score also significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.021) in controls but not in patients (p > 0.05). Conclusions: This study found that the A allele of the TCF4 rs2958182 polymorphism was the risk allele of schizophrenia, and was associated with lower cognitive performance in language in schizophrenia and delayed memory in controls. In contrast, the T allele of this polymorphism was found to be the schizophrenia risk allele in another study in Han Chinese people.]]> Sat 24 Mar 2018 07:16:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22863 IL-1beta-511C/T polymorphism and smoking behavior in schizophrenia versus healthy controls in a Chinese population. The IL-1beta-511C/T polymorphism was genotyped in 638 male patients with chronic schizophrenia (smoker/never-smoker=486/152) and 469 male controls (smoker/never-smoker=243/226). The cigarettes smoked per day, the Heaviness of Smoking Index (HSI) and the Fagerstrom Test for nicotine dependence (FTND) were assessed. Patients were also rated on the Positive and Negative Syndrome Scale (PANSS). The results showed no significant differences in genotype and allele distribution between patients and controls, and between smokers and never-smokers in either the patient or control group. However, in patients, smokers with the C/C genotype had significantly higher HSI (p<0.005) and FTND (p<0.05) scores than smokers with the T/T genotype, without significant differences in controls. Furthermore, there was a linear positive correlation between the number of C alleles and the HSI (p<0.005) in patients. Our findings suggest that the IL-1beta-511C/T polymorphism may not be related to schizophrenia or smoking status in Chinese individuals, but may affect the severity of nicotine dependence among male smokers with schizophrenia.]]> Sat 24 Mar 2018 07:16:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22081 Sat 24 Mar 2018 07:15:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49848 Mon 05 Jun 2023 15:49:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37045 Fri 07 Aug 2020 14:34:14 AEST ]]>